Adventure

Adventure is also known as PVE, which stands for Player vs Environment. In this mode you are going to play against NPC.

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Arena or PvP

This means you are battling against other players, and you will be ranked in the leaderboard based on your Match-Making Rating (MMR), both on- and offseason. Ranking high in Arena during Seasons come with the benefit of getting rewards in AXS.

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You can play both Adventure and Arena mode with or without energy, however what you'll earn by winning a match will differ.

Adventure vs Arena

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References

https://www.axiehandbook.com/playing-the-game/battle-basics

https://axie.substack.com/p/axie-infinity-community-alpha-guide